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<http://opendata.unex.es/recurso/ciencia-tecnologia/investigacion/publicaciones/Publicacion/2018-718> ou:vecesCitado "110";
    dcterms:creator "Gómez-Suaga P.";
    a ou:Publicacion;
    vivo:identifier "2018-718";
    ou:bibtex "@article{733cd1fea4db4dcc9ce67887caf830ff,\n  title     = 'ER-mitochondria signaling in Parkinson's disease review-article',\n  abstract  = 'Mitochondria form close physical contacts with a specialized domain of the endoplasmic reticulum (ER), known as the mitochondria-associated membrane (MAM). This association constitutes a key signaling hub to regulate several fundamental cellular processes. Alterations in ER-mitochondria signaling have pleiotropic effects on a variety of intracellular events resulting in mitochondrial damage, Ca2+ dyshomeostasis, ER stress and defects in lipid metabolism and autophagy. Intriguingly, many of these cellular processes are perturbed in neurodegenerative diseases. Furthermore, increasing evidence highlights that ER-mitochondria signaling contributes to these diseases, including Parkinson's disease (PD). PD is the second most common neurodegenerative disorder, for which effective mechanism-based treatments remain elusive. Several PD-related proteins localize at mitochondria or MAM and have been shown to participate in ER-mitochondria signaling regulation. Likewise, PD-related mutations have been shown to damage this signaling. Could ER-mitochondria associations be the link between pathogenic mechanisms involved in PD, providing a common mechanism? Would this provide a pharmacological target for treating this devastating disease? In this review, we aim to summarize the current knowledge of ER-mitochondria signaling and the recent evidence concerning damage to this signaling in PD.',\n  author    = 'Patricia G{\\'o}mez-Suaga and {Bravo-San Pedro}, {Jos{\\'e} M.} and Gonz{\\'a}lez-Polo, {Rosa A.} and Fuentes, {J. M.} and Mireia Niso-Santano',\n  year      = '2018',\n  month     = mar,\n  day       = '1',\n  doi       = '10.1038/s41419-017-0079-3',\n  language  = 'English',\n  volume    = '9',\n  journal   = 'Cell Death and Disease',\n  issn      = '2041-4889',\n  publisher = 'Nature Publishing Group',\n  number    = '3',\n}";
    dcterms:publisher "Cell Death and Disease";
    vcard:url <https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85042859594&origin=inward>;
    bibo:volume "9";
    ou:tipoPublicacion "Review";
    dcterms:contributor "Gomez-Suaga P., Bravo-San Pedro J.M., Gonzalez-Polo R.A., Fuentes J.M., Niso-Santano M.";
    ou:urlOrcid <https://kclpure.kcl.ac.uk/portal/en/publications/733cd1fe-a4db-4dcc-9ce6-7887caf830ff>;
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    bibo:eissn "2041-4889";
    bibo:doi "10.1038/s41419-017-0079-3";
    fabio:hasPublicationYear "2018";
    dcterms:title "ER-mitochondria signaling in Parkinson's disease review-article";
    ou:publicadaEnRevista <http://opendata.unex.es/recurso/ciencia-tecnologia/investigacion/revistas/Revista/2018-4851>, <http://opendata.unex.es/recurso/ciencia-tecnologia/investigacion/revistas/Revista/2018-4851>.
<http://opendata.unex.es/recurso/educacion/universidad/personal/e529f24d85062c120b2d2ce7f35780c0-jose-manuel-fuentes-rodriguez> ou:tienePublicacion <http://opendata.unex.es/recurso/ciencia-tecnologia/investigacion/publicaciones/Publicacion/2018-718>.
<http://opendata.unex.es/recurso/educacion/universidad/personal/8fe778b99f5349734cc3c727e08db599-mireia-niso-santano> ou:tienePublicacion <http://opendata.unex.es/recurso/ciencia-tecnologia/investigacion/publicaciones/Publicacion/2018-718>.
<http://opendata.unex.es/recurso/educacion/universidad/personal/03301885b8214f1b43752b6676c63279-patricia-maria-gomez-suaga> ou:tienePublicacion <http://opendata.unex.es/recurso/ciencia-tecnologia/investigacion/publicaciones/Publicacion/2018-718>.
<http://opendata.unex.es/recurso/educacion/universidad/personal/75ba9fde25928081ea147fe894cd1057-rosa-ana-gonzalez-polo> ou:tienePublicacion <http://opendata.unex.es/recurso/ciencia-tecnologia/investigacion/publicaciones/Publicacion/2018-718>.