ISAAC JARDÍN POLO

Literals

• ou:categoriaPDI
  • A0504-PROFESOR TITULAR DE UNIVERSIDAD
• aiiso:code
  • a2905a8db31900b241771d8526fd5093
• ou:dedicacionPDI
  • TIEMPO COMPLETO
• foaf:firstName
  • ISAAC
• ou:indiceHscopus
  • 34
• foaf:lastName
  • JARDÍN POLO
• foaf:name
  • ISAAC JARDÍN POLO
• vivo:orcidId
  • 0000000345758264
• ou:orcidURL
  • http://orcid.org/0000000345758264
• vivo:scopusId
  • 8604303200

Typed Literals

• ou:esDoctor
  • True (xsd:boolean)
• ou:personalActual
  • True (xsd:boolean)

Relations

• teach:teacherOf
  • ENDOCRINOLOGÍA MOLECULAR
  • ACTIVIDADES FÍSICAS EN PERSONAS CON PROBLEMAS DE SALUD CRÓNICOS: CARDIOVASCULARES Y METABÓLICOS
  • ACTIVIDADES FÍSICAS EN PERSONAS CON PROBLEMAS CRÓNICOS: CARDÍACOS Y METABÓLICOS
  • ACTIVIDADES FÍSICAS EN PERSONAS CON PROBLEMAS CRÓNICOS: CARDÍACOS Y METABÓLICOS
  • ENDOCRINOLOGÍA Y REGULACIÓN METABÓLICA
  • FISIOLOGÍA ANIMAL
  • FISIOLOGÍA HUMANA
  • FISIOLOGÍA HUMANA
  • FISIOLOGÍA HUMANA
  • HEMATOLOGÍA Y HEMOTERAPIA
  • HEMATOLOGÍA Y HEMOTERAPIA
Show less
• ou:tienePublicacion
  • (−)‑Oleocanthal inhibits proliferation and migration by modulating Ca²⁺ entry through TRPC6 in breast cancer cells
  • A Coiled-coil Clamp Controls Both Conformation and Clustering of Stromal Interaction Molecule 1 (STIM1)
  • A MULTI-LAYERED FIBRIN COATING ALLOWS MENSTRUAL BLOOD-DERIVED MESENCHYMAL STROMAL CELLS ADHESION ON POLYPROPYLENE SURGICAL MESHES
  • A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca²⁺ permeation and SOCE-induced gene transcription
  • A fibrin coating method of polypropylene meshes enables the adhesion of menstrual blood-derived mesenchymal stromal cells: A new delivery strategy for stem cell-based therapies
  • Acidic-store depletion is required for human platelet aggregation
  • Adenylyl cyclase type 8 overexpression impairs phosphorylation-dependent orai1 inactivation and promotes migration in MDA-MB-231 breast cancer cells
  • Apelin: an antithrombotic factor that inhibits platelet function
  • Attenuated store-operated divalent cation entry and association between STIM1, Orai1, hTRPC1 and hTRPC6 in platelets from type 2 diabetic patients
  • Ca²⁺ leakage rate from agonist-sensitive intracellular pools is altered in platelets from patients with type 2 diabetes
  • Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca²⁺ influx
  • Cholesterol Regulates Orai1 Function
  • Cholesterol modulates Orai1 channel function
  • Cinnamtannin B-1 as an antioxidant and platelet aggregation inhibitor
  • Complex role of STIM1 in the activation of store-independent Orai1/3 channels
  • Correction to: Orai2 Modulates Store-Operated Ca2+ Entry and Cell Cycle Progression in Breast Cancer Cells (Cancers, (2021), 14, 1, (114), 10.3390/cancers14010114)
  • Cross-Talk Between the Adenylyl Cyclase/cAMP Pathway and Ca²⁺ Homeostasis
  • Description of a new quantitative method to assess mitochondrial distribution pattern in mature equine oocytes
  • Differential involvement of thrombin receptors in Ca²⁺ release from two different intracellular stores in human platelets
  • Dynamic interaction of hTRPC6 with the Orai1-STIM1 complex or hTRPC3 mediates its role in capacitative or non-capacitative Ca2⁺ entry pathways
  • EFHB is a novel cytosolic Ca ²⁺ sensor that modulates STIM1-SARAF interaction
  • Effect of homocysteine on calcium mobilization and platelet function in type 2 diabetes mellitus
  • Endogenously generated reactive oxygen species reduce PMCA activity in platelets from patients with non-insulin-dependent diabetes mellitus
  • Filamin A Modulates Store-Operated Ca²⁺ Entry by Regulating STIM1 (Stromal Interaction Molecule 1)-Orai1 Association in Human Platelets
  • Filamin A modulates platelet function
  • Fine-tuning of microRNAs in type 2 diabetes mellitus
  • Fine-tuning of store-operated calcium entry by fast and slow Ca²⁺-dependent inactivation: Involvement of SARAF
  • Flavonoids and platelet-derived thrombotic disorders
  • Functional differences in agonist-induced plasma membrane expression of Orai1α and Orai1β
  • Functional relevance of the de novo coupling between hTRPC1 and type II IP<inf>3</inf> receptor in store-operated Ca²⁺ entry in human platelets
  • Functional role of TRPC6 and STIM2 in cytosolic and endoplasmic reticulum Ca²⁺ content in resting estrogen receptor-positive breast cancer cells
  • Homer proteins in Ca²⁺ entry
  • Homers regulate calcium entry and aggregation in human platelets: A role for Homers in the association between STIM1 and Orai1
  • Homocysteine, intracellular signaling and thrombotic disorders
  • Hydrogen peroxide and peroxynitrite enhance Ca²⁺ mobilization and aggregation in platelets from type 2 diabetic patients
  • Identification and function of exchange proteins activated directly by cyclic AMP (Epac) in mammalian spermatozoa
  • Intracellular Ca²⁺ store depletion induces the formation of macromolecular complexes involving hTRPC1, hTRPC6, the type II IP<inf>3</inf> receptor and SERCA3 in human platelets
  • Intracellular Calcium Release from Human Platelets: Different Messengers for Multiple Stores
  • Involvement of SNARE proteins in thrombin-induced platelet aggregation: Evidence for the relevance of Ca²⁺ entry
  • Involvement of stanniocalcins in the deregulation of glycaemia in obese mice and type 2 diabetic patients
  • Lipid rafts are essential for the regulation of SOCE by plasma membrane resident STIM1 in human platelets
  • Melatonin downregulates TRPC6, impairing store-operated calcium entry in triple-negative breast cancer cells
  • Melatonin, as an adjuvant-like agent, enhances platelet responsiveness
  • Molecular Basis and Regulation of Store-Operated Calcium Entry
  • Molecular mechanisms of STIM/Orai communication
  • ORAL ABSTRACT: APELIN DISPLAYS AN ANTITHROMBOTIC FUNCTION DEPENDANT OF CALCIUM RESPONSE
  • Orai1 and Orai2 mediate store-operated calcium entry that regulates HL60 cell migration and FAK phosphorylation
  • Orai1 mediates the interaction between STIM1 and hTRPC1 and regulates the mode of activation of hTRPC1-forming Ca²⁺ channels
  • Orai1α and Orai1β support calcium entry and mammosphere formation in breast cancer stem cells
  • Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells
  • Orai2 modulates store-operated ca²⁺ entry and cell cycle progression in breast cancer cells
  • Pharmacology of TRP channels in the vasculature
  • Phosphatidylinositol 4,5-bisphosphate enhances store-operated calcium entry through hTRPC6 channel in human platelets
  • Physical properties of two types of calcium stores and SERCAs in human platelets
  • Regulation of platelet function by Orai, STIM and TRP
  • Regulators of G-Protein-Signaling Proteins: Negative Modulators of G-Protein-Coupled Receptor Signaling
  • Role of Orai-family channels in the activation and regulation of transcriptional activity
  • Role of STIM2 in cell function and physiopathology
  • Role of lipid rafts in the interaction between hTRPC1, Orai1 and STIM1
  • Role of orai3 in the pathophysiology of cancer
  • Role of oxidant scavengers in the prevention of Ca²⁺ homeostasis disorders
  • STIM and calcium channel complexes in cancer
  • STIM and orai1 variants in store-operated calcium entry
  • STIM1 and STIM2 are located in the acidic Ca²⁺ stores and associates with Orai1 upon depletion of the acidic stores in human platelets
  • STIM1 phosphorylation at Y³¹⁶ modulates its interaction with SARAF and the activation of SOCE and I<inf>CRAC</inf>
  • STIM1 regulates acidic Ca²⁺ store refilling by interaction with SERCA3 in human platelets
  • STIM1 tyrosine-phosphorylation is required for STIM1-Orai1 association in human platelets
  • Saraf and efhb modulate store-operated ca²⁺ entry and are required for cell proliferation, migration and viability in breast cancer cells
  • Secretion of Interleukin 6 in Human Skeletal Muscle Cultures Depends on Ca²⁺ Signalling
  • Similarities and Differences between the Orai1 Variants: Orai1α and Orai1β
  • Store-Operated Calcium Entry and Its Implications in Cancer Stem Cells
  • Store-Operated Calcium Entry in Breast Cancer Cells Is Insensitive to Orai1 and STIM1 N-Linked Glycosylation
  • Store-independent Orai1-mediated Ca ²⁺ entry and cancer
  • Store-operated Ca ²⁺ entry in breast cancer cells: Remodeling and functional role
  • Store-operated Ca²⁺ entry is sensitive to the extracellular Ca²⁺ concentration through plasma membrane STIM1
  • TRPC 1 acts as a Negative Regulator for TRPV6 Mediated Ca<SUP>2+</SUP> Influx
  • TRPC channels in the SOCE scenario
  • TRPC3 regulates agonist-stimulated Ca²⁺ mobilization by mediating the interaction between type I inositol 1,4,5-trisphosphate receptor, RACK1, and Orai1
  • TRPC6 channel and its implications in breast cancer: an overview
  • TRPs in pain sensation
  • The Ca²⁺ Sensor STIM in Human Diseases
  • The STIM1/Orai signaling machinery
  • The STIM1: Orai interaction
  • The TRPC ion channels: Association with orai1 and STIM1 proteins and participation in capacitative and non-capacitative calcium entry
  • The TRPV1 ion channel is expressed in human but not mouse platelets
  • The complex role of store operated calcium entry pathways and related proteins in the function of cardiac, skeletal and vascular smooth muscle cells
  • The extended transmembrane orai1 N-terminal (ETON) region combines binding interface and gate for orai1 activation by STIM1
  • The orai1-ac8 interplay: How breast cancer cells escape from orai1 channel inactivation
  • The polybasic lysine-rich domain of plasma membrane-resident STIM1 is essential for the modulation of store-operated divalent cation entry by extracellular calcium
  • The store-operated Ca²⁺ channel Orai1α is required for agonist-evoked NF-κB activation by a mechanism dependent on PKCβ2
  • Transient receptor potential channels in human platelets: Expression and functional role
  • Trpc6 channels are required for proliferation, migration and invasion of breast cancer cell lines by modulation of orai1 and orai3 surface exposure
  • Urtica dioica extract reduces platelet hyperaggregability in type 2 diabetes mellitus by inhibition of oxidant production, Ca²⁺ mobilization and protein tyrosine phosphorylation
  • Vaccination prepartum enhances the beneficial effects of melatonin on the immune response and reduces platelet responsiveness in sheep
Show less
• ou:perteneceAGrupoInvestigacion
  • FISIOLOGIA CELULAR
• ou:adscritoADepartamento
  • FISIOLOGÍA
• ou:imparteDocenciaEnArea
  • FISIOLOGÍA
• ou:adscritoACentro
  • Facultad De Veterinaria

Inverse Relations

• Has related: ou:autorTesis
  • Complejos Stim1-Orai1-Trpc En La Entrada De Calcio En Plaquetas Humanas
• Has related: ou:directorTesis
  • Papel Del Remodelado De La Entrada De Calcio En El Desarrollo Tumoral

Inverse Blank Nodes

• Has related: org:member
  • [Anonymous resource (nodeID://b7804127)
    (org:Membership)
    • org:member ISAAC JARDÍN POLO
    • org:organization Instituto Universitario de Biomarcadores de Patologías Moleculares
    ]

Blank Nodes

• org:hasMembership
  • [Anonymous resource (nodeID://b7927452)
    (org:Membership)
    • org:memberDuring Anonymous resource(nodeID://b7927453)
    • org:role Anonymous resource(nodeID://b7927454)
    ]
  • [Anonymous resource (nodeID://b7927455)
    (org:Membership)
    • org:role Anonymous resource(nodeID://b7927457)
    • org:memberDuring Anonymous resource(nodeID://b7927456)
    ]
  • [Anonymous resource (nodeID://b7927467)
    (org:Membership)
    • org:role Anonymous resource(nodeID://b7927469)
    • org:memberDuring Anonymous resource(nodeID://b7927468)
    ]
  • [Anonymous resource (nodeID://b7927458)
    (org:Membership)
    • org:memberDuring Anonymous resource(nodeID://b7927459)
    • org:role Anonymous resource(nodeID://b7927460)
    ]
  • [Anonymous resource (nodeID://b7927461)
    (org:Membership)
    • org:role Anonymous resource(nodeID://b7927463)
    • org:memberDuring Anonymous resource(nodeID://b7927462)
    ]
  • [Anonymous resource (nodeID://b7927464)
    (org:Membership)
    • org:memberDuring Anonymous resource(nodeID://b7927465)
    • org:role Anonymous resource(nodeID://b7927466)
    ]
Show less
• swrcfe:assignedTo
  • [Anonymous resource (nodeID://b7722483)
    (swrcfe:AssignedPerson)
    • swrcfe:role Investigador principal
    • swrcfe:project ALTERACIÓN DE LOS MECANISMOS QUE MEDIAN Y REGULAN LA ENTRADA DE CALCIO EN EL CÁNCER DE MAMA.
    ]
  • [Anonymous resource (nodeID://b7722489)
    (swrcfe:AssignedPerson)
    • swrcfe:role Investigador
    • swrcfe:project REMODELADO DE LA EXPRESIÓN DE STIM Y ORAI Y DE SUS MECANISMOS REGULADORES EN EL CÁNCER DE MAMA
    ]
  • [Anonymous resource (nodeID://b7722482)
    (swrcfe:AssignedPerson)
    • swrcfe:role Investigador
    • swrcfe:project ESTUDIO DE LA INTERRELACIÓN DE LOS CANALES CAPACITATIVOS FORMADOS POR ORAI Y TRPC, SUS CARACTERÍSTICAS FUNCIONALES Y SU RELEVANCIA EN LA FISIOPATOLOGÍA DEL CÁNCER DE MAMA
    ]
  • [Anonymous resource (nodeID://b7722486)
    (swrcfe:AssignedPerson)
    • swrcfe:role Investigador
    • swrcfe:project RELEVANCIA DE LOS CANALES ORAI EN LAS CARACTERÍSTICAS Y PROGRESIÓN DEL CÁNCER DE MAMA
    ]
  • [Anonymous resource (nodeID://b7722484)
    (swrcfe:AssignedPerson)
    • swrcfe:role Investigador principal
    • swrcfe:project CONCESIÓN DE SUBVENCIÓN PARA LA CONTRATACIÓN LABORAL DE DOCTORES POR CENTROS DE INVESTIGACIÓN Y DESARROLLO (SUBPROGRAMA JUAN DE LA CIERVA)
    ]
  • [Anonymous resource (nodeID://b7722487)
    (swrcfe:AssignedPerson)
    • swrcfe:role Investigador
    • swrcfe:project ADQUISICIÓN DE UN SISTEMA DE VIDEOMICROSCOPÍA PARA CULTIVO CELULAR 3D.
    ]
  • [Anonymous resource (nodeID://b7722488)
    (swrcfe:AssignedPerson)
    • swrcfe:role Investigador
    • swrcfe:project GRUPO FISIOLOGÍA CELULAR
    ]
  • [Anonymous resource (nodeID://b7722485)
    (swrcfe:AssignedPerson)
    • swrcfe:role Investigador
    • swrcfe:project ESTUDIO DEL PAPEL DE LAS VARIANTES DEL CANAL ORAI 1, ORAI 1 ALFA Y ORAI 1 BETA, EN LA FUNCIÓN CELULAR.
    ]
  • [Anonymous resource (nodeID://b7722481)
    (swrcfe:AssignedPerson)
    • swrcfe:role Investigador
    • swrcfe:project AYUDA AL GRUPO DE INVESTIGACIÓN DENOMINADO "FISIOLOGIA CELULAR"
    ]
Show less
• foaf:account
  • [Anonymous resource (nodeID://b250858)
    (foaf:OnlineAccount)
    • foaf:accountServiceHomePage https://twitter.com/
    • foaf:accountName IsaacJardin
    ]
  • [Anonymous resource (nodeID://b250859)
    (foaf:OnlineAccount)
    • foaf:accountName Isaac_Jardin
    • foaf:accountServiceHomePage https://www.researchgate.net/
    ]