http://opendata.unex.es/recurso/ciencia-tecnologia/investigacion/publicaciones/Publicacion/2018-718
Literals
- ou:vecesCitado
- dcterms:creator
- ou:bibtex
- @article{733cd1fea4db4dcc9ce67887caf830ff,
title = 'ER-mitochondria signaling in Parkinson's disease review-article',
abstract = 'Mitochondria form close physical contacts with a specialized domain of the endoplasmic reticulum (ER), known as the mitochondria-associated membrane (MAM). This association constitutes a key signaling hub to regulate several fundamental cellular processes. Alterations in ER-mitochondria signaling have pleiotropic effects on a variety of intracellular events resulting in mitochondrial damage, Ca2+ dyshomeostasis, ER stress and defects in lipid metabolism and autophagy. Intriguingly, many of these cellular processes are perturbed in neurodegenerative diseases. Furthermore, increasing evidence highlights that ER-mitochondria signaling contributes to these diseases, including Parkinson's disease (PD). PD is the second most common neurodegenerative disorder, for which effective mechanism-based treatments remain elusive. Several PD-related proteins localize at mitochondria or MAM and have been shown to participate in ER-mitochondria signaling regulation. Likewise, PD-related mutations have been shown to damage this signaling. Could ER-mitochondria associations be the link between pathogenic mechanisms involved in PD, providing a common mechanism? Would this provide a pharmacological target for treating this devastating disease? In this review, we aim to summarize the current knowledge of ER-mitochondria signaling and the recent evidence concerning damage to this signaling in PD.',
author = 'Patricia G{\'o}mez-Suaga and {Bravo-San Pedro}, {Jos{\'e} M.} and Gonz{\'a}lez-Polo, {Rosa A.} and Fuentes, {J. M.} and Mireia Niso-Santano',
year = '2018',
month = mar,
day = '1',
doi = '10.1038/s41419-017-0079-3',
language = 'English',
volume = '9',
journal = 'Cell Death and Disease',
issn = '2041-4889',
publisher = 'Nature Publishing Group',
number = '3',
}
- dcterms:contributor
- Gomez-Suaga P., Bravo-San Pedro J.M., Gonzalez-Polo R.A., Fuentes J.M., Niso-Santano M.
- ou:urlScopus
- dcterms:title
- ER-mitochondria signaling in Parkinson's disease review-article
- ou:tipoPublicacion
- dcterms:publisher
- vivo:identifier
- fabio:hasPublicationYear
- bibo:doi
- 10.1038/s41419-017-0079-3
- ou:eid
- bibo:eissn
- vcard:url
- ou:urlOrcid
- bibo:volume
Typed Literals