PUBLICACIÓN

Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy

ACCEDER A LA PUBLICACIÓN: Scopus Orcid

Vuorinen A. et al.

2021 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Drug Discovery (Q1), Medicine (miscellaneous) (Q1), Organic Chemistry (Q1), Pharmacology (Q1)

JCR: 7.088

SJR: 1.054

CITAS

11

DOI

10.1016/j.ejmech.2021.113431

EID

2-s2.0-85108022709

ISSN

0223-5234

EISSN

1768-3254

BIBTEX

@article{Vuorinen_2021, doi = {10.1016/j.ejmech.2021.113431}, url = {https://doi.org/10.1016%2Fj.ejmech.2021.113431}, year = 2021, month = {aug}, publisher = {Elsevier {BV}}, volume = {220}, pages = {113431}, author = {Aini Vuorinen and Isabel V.L. Wilkinson and Maria Chatzopoulou and Ben Edwards and Sarah E. Squire and Rebecca J. Fairclough and Noelia Araujo Bazan and Josh A. Milner and Daniel Conole and James R. Donald and Nandini Shah and Nicky J. Willis and R. Fernando Mart{\'{\i}}nez and Francis X. Wilson and Graham M. Wynne and Stephen G. Davies and Kay E. Davies and Angela J. Russell}, title = {Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy}, journal = {European Journal of Medicinal Chemistry}}

AUTORES DE LA UEX

Rafael Fernando Martínez Vázquez

OTRAS PUBLICACIONES DE INTERÉS

An Efficient And Highly Diastereoselective Synthesis Of C-Glycosylated 1,3-Oxazolidines From N-Methyl-D-Glucamine
Catalytic Screening For 1,2-Diol Protection: A Saccharose-Derived Hydrothermal Carbon Showcases Enhanced Performance
Novel Graphitic Oxynitrides As Photocatalysts For Sustainable H2 Production And Co2 Valorization. The Importance Of Self-Assembly For Catalytic Activity
Catalytic Screening For 1,2-Diol Protection: A Saccharose-Derived Hydrothermal Carbon Showcases Enhanced Performance
Novel Graphitic Oxynitrides As Photocatalysts For Sustainable H2 Production And Co2 Valorization. The Importance Of Self-Assembly For Catalytic Activity
Tuning Synthesis And Sonochemistry Forges Learning And Enhances Educational Training: Protection Of 1,3-Diols Under Heterogeneous Catalysis As Sustainable Case Study
Novel Graphitic Oxynitrides As Photocatalysts For Sustainable H2 Production And Co2 Valorization. The Importance Of Self-Assembly For Catalytic Activity
Tuning Synthesis And Sonochemistry Forges Learning And Enhances Educational Training: Protection Of 1,3-Diols Under Heterogeneous Catalysis As Sustainable Case Study
Síntesis De Acetales Derivados De 1,2-Dioles En Presencia De Catalizadores Ácidos Carbonosos
Tuning Synthesis And Sonochemistry Forges Learning And Enhances Educational Training: Protection Of 1,3-Diols Under Heterogeneous Catalysis As Sustainable Case Study
Síntesis De Acetales Derivados De 1,2-Dioles En Presencia De Catalizadores Ácidos Carbonosos
A True Reverse Anomeric Effect Does Exist After All: A Hydrogen Bonding Stereocontrolling Effect In 2-Iminoaldoses
Síntesis De Acetales Derivados De 1,2-Dioles En Presencia De Catalizadores Ácidos Carbonosos
A True Reverse Anomeric Effect Does Exist After All: A Hydrogen Bonding Stereocontrolling Effect In 2-Iminoaldoses
University Students’ Introduction To Science Communication
A True Reverse Anomeric Effect Does Exist After All: A Hydrogen Bonding Stereocontrolling Effect In 2-Iminoaldoses
University Students’ Introduction To Science Communication
¿sabe El Estudiantado Universitario Hablar En Público?
University Students’ Introduction To Science Communication
¿sabe El Estudiantado Universitario Hablar En Público?
Preparación De Carbamatos A Partir De Aminas Aromáticas Mediante Catálisis Heterogénea
¿sabe El Estudiantado Universitario Hablar En Público?
Preparación De Carbamatos A Partir De Aminas Aromáticas Mediante Catálisis Heterogénea
An Eco-Friendly And Switchable Carbon-Based Catalyst For Protection-Deprotection Of Vicinal Diols
Preparación De Carbamatos A Partir De Aminas Aromáticas Mediante Catálisis Heterogénea
An Eco-Friendly And Switchable Carbon-Based Catalyst For Protection-Deprotection Of Vicinal Diols
Developing Public Speaking Skills In European Education Area Students: Reflections From Seven Years Of Experience
An Eco-Friendly And Switchable Carbon-Based Catalyst For Protection-Deprotection Of Vicinal Diols
Developing Public Speaking Skills In European Education Area Students: Reflections From Seven Years Of Experience
Mechanistic Insights Into The Oxidative Degradation Of Formic And Oxalic Acids With Ozone And Oh Radical. A Computational Rationale
Developing Public Speaking Skills In European Education Area Students: Reflections From Seven Years Of Experience
Mechanistic Insights Into The Oxidative Degradation Of Formic And Oxalic Acids With Ozone And Oh Radical. A Computational Rationale
Novel Antagonist Of The Type 2 Lysophosphatidic Acid Receptor (Lpa2), Ucm-14216, Ameliorates Spinal Cord Injury In Mice
Mechanistic Insights Into The Oxidative Degradation Of Formic And Oxalic Acids With Ozone And Oh Radical. A Computational Rationale
Novel Antagonist Of The Type 2 Lysophosphatidic Acid Receptor (Lpa2), Ucm-14216, Ameliorates Spinal Cord Injury In Mice
On The Origin Of Sugar Handedness: Facts, Hypotheses And Missing Links-A Review
Novel Antagonist Of The Type 2 Lysophosphatidic Acid Receptor (Lpa2), Ucm-14216, Ameliorates Spinal Cord Injury In Mice
On The Origin Of Sugar Handedness: Facts, Hypotheses And Missing Links-A Review
Discovery And Mechanism Of Action Studies Of 4,6-Diphenylpyrimidine-2-Carbohydrazides As Utrophin Modulators For The Treatment Of Duchenne Muscular Dystrophy
On The Origin Of Sugar Handedness: Facts, Hypotheses And Missing Links-A Review
Discovery And Mechanism Of Action Studies Of 4,6-Diphenylpyrimidine-2-Carbohydrazides As Utrophin Modulators For The Treatment Of Duchenne Muscular Dystrophy
Targeting The Ftsz Allosteric Binding Site With A Novel Fluorescence Polarization Screen, Cytological And Structural Approaches For Antibacterial Discovery
Discovery And Mechanism Of Action Studies Of 4,6-Diphenylpyrimidine-2-Carbohydrazides As Utrophin Modulators For The Treatment Of Duchenne Muscular Dystrophy
Targeting The Ftsz Allosteric Binding Site With A Novel Fluorescence Polarization Screen, Cytological And Structural Approaches For Antibacterial Discovery
Organic Sonochemistry: A Chemist's Timely Perspective On Mechanisms And Reactivity
Targeting The Ftsz Allosteric Binding Site With A Novel Fluorescence Polarization Screen, Cytological And Structural Approaches For Antibacterial Discovery
Organic Sonochemistry: A Chemist's Timely Perspective On Mechanisms And Reactivity
A Novel Agonist Of The Type 1 Lysophosphatidic Acid Receptor (Lpa1), Ucm-05194, Shows Efficacy In Neuropathic Pain Amelioration
Organic Sonochemistry: A Chemist's Timely Perspective On Mechanisms And Reactivity
A Novel Agonist Of The Type 1 Lysophosphatidic Acid Receptor (Lpa1), Ucm-05194, Shows Efficacy In Neuropathic Pain Amelioration
Imine Or Enamine? Insights And Predictive Guidelines From The Electronic Effect Of Substituents In H-Bonded Salicylimines
A Novel Agonist Of The Type 1 Lysophosphatidic Acid Receptor (Lpa1), Ucm-05194, Shows Efficacy In Neuropathic Pain Amelioration
Imine Or Enamine? Insights And Predictive Guidelines From The Electronic Effect Of Substituents In H-Bonded Salicylimines
Mutarotation Of Aldoses: Getting A Deeper Knowledge Of A Classic Equilibrium Enabled By Computational Analyses
Imine Or Enamine? Insights And Predictive Guidelines From The Electronic Effect Of Substituents In H-Bonded Salicylimines
Mutarotation Of Aldoses: Getting A Deeper Knowledge Of A Classic Equilibrium Enabled By Computational Analyses
A Novel Agonist Of The Type 1 Lysophosphatidic Acid Receptor (Lpa1), Ucm-05194, Shows Efficacy In Neuropathic Pain Amelioration.
Mutarotation Of Aldoses: Getting A Deeper Knowledge Of A Classic Equilibrium Enabled By Computational Analyses
A Novel Agonist Of The Type 1 Lysophosphatidic Acid Receptor (Lpa1), Ucm-05194, Shows Efficacy In Neuropathic Pain Amelioration.
Isolation From Stevia Rebaudiana Of Dmdp Acetic Acid, A Novel Iminosugar Amino Acid: Synthesis And Glycosidase Inhibition Profile Of Glycine And Β-Alanine Pyrrolidine Amino Acids
A Novel Agonist Of The Type 1 Lysophosphatidic Acid Receptor (Lpa1), Ucm-05194, Shows Efficacy In Neuropathic Pain Amelioration.
Isolation From Stevia Rebaudiana Of Dmdp Acetic Acid, A Novel Iminosugar Amino Acid: Synthesis And Glycosidase Inhibition Profile Of Glycine And Β-Alanine Pyrrolidine Amino Acids
Cycloadditions With Mesoionic Dipoles: Strategy And Control
Isolation From Stevia Rebaudiana Of Dmdp Acetic Acid, A Novel Iminosugar Amino Acid: Synthesis And Glycosidase Inhibition Profile Of Glycine And Β-Alanine Pyrrolidine Amino Acids
Cycloadditions With Mesoionic Dipoles: Strategy And Control
The Dimroth Rearrangement As A Probable Cause For Structural Misassignments In Imidazo[1,2-A]pyrimidines: A 15n-Labelling Study And An Easy Method For The Determination Of Regiochemistry
Cycloadditions With Mesoionic Dipoles: Strategy And Control
The Dimroth Rearrangement As A Probable Cause For Structural Misassignments In Imidazo[1,2-A]pyrimidines: A 15n-Labelling Study And An Easy Method For The Determination Of Regiochemistry
The Structural Assembly Switch Of Cell Division Protein Ftsz Probed With Fluorescent Allosteric Inhibitors
The Dimroth Rearrangement As A Probable Cause For Structural Misassignments In Imidazo[1,2-A]pyrimidines: A 15n-Labelling Study And An Easy Method For The Determination Of Regiochemistry
The Structural Assembly Switch Of Cell Division Protein Ftsz Probed With Fluorescent Allosteric Inhibitors
Cycloadditions With Mesoionic Dipoles: Strategy And Control
The Structural Assembly Switch Of Cell Division Protein Ftsz Probed With Fluorescent Allosteric Inhibitors
Cycloadditions With Mesoionic Dipoles: Strategy And Control
Structural Essentials For Β-: N -Acetylhexosaminidase Inhibition By Amides Of Prolines, Pipecolic And Azetidine Carboxylic Acids
Cycloadditions With Mesoionic Dipoles: Strategy And Control
Structural Essentials For Β-: N -Acetylhexosaminidase Inhibition By Amides Of Prolines, Pipecolic And Azetidine Carboxylic Acids
Nine Of 16 Stereoisomeric Polyhydroxylated Proline Amides Are Potent Β-N-Acetylhexosaminidase Inhibitors
Structural Essentials For Β-: N -Acetylhexosaminidase Inhibition By Amides Of Prolines, Pipecolic And Azetidine Carboxylic Acids
Nine Of 16 Stereoisomeric Polyhydroxylated Proline Amides Are Potent Β-N-Acetylhexosaminidase Inhibitors
Carbohydrate Derived Bicyclic Azetidin-3-Ones As Scaffolds For Highly Functionalized Azetidines
Nine Of 16 Stereoisomeric Polyhydroxylated Proline Amides Are Potent Β-N-Acetylhexosaminidase Inhibitors
Carbohydrate Derived Bicyclic Azetidin-3-Ones As Scaffolds For Highly Functionalized Azetidines
Short And Sweet: D-Glucose To L-Glucose And L-Glucuronic Acid
Carbohydrate Derived Bicyclic Azetidin-3-Ones As Scaffolds For Highly Functionalized Azetidines
Short And Sweet: D-Glucose To L-Glucose And L-Glucuronic Acid
Synthesis Of The Enantiomers Of Xylnac And Lyxnac: Comparison Of Β-N-Acetylhexosaminidase Inhibition By The 8 Stereoisomers Of 2-N-Acetylamino-1,2,4-Trideoxy-1,4-Iminopentitols
Short And Sweet: D-Glucose To L-Glucose And L-Glucuronic Acid
Synthesis Of The Enantiomers Of Xylnac And Lyxnac: Comparison Of Β-N-Acetylhexosaminidase Inhibition By The 8 Stereoisomers Of 2-N-Acetylamino-1,2,4-Trideoxy-1,4-Iminopentitols
Kurz Und Knapp:l-Glucose Undl-Glucuronsäure Ausd-Glucose
Synthesis Of The Enantiomers Of Xylnac And Lyxnac: Comparison Of Β-N-Acetylhexosaminidase Inhibition By The 8 Stereoisomers Of 2-N-Acetylamino-1,2,4-Trideoxy-1,4-Iminopentitols
Kurz Und Knapp:l-Glucose Undl-Glucuronsäure Ausd-Glucose
Hydrazones From Hydroxy Naphthaldehydes. Part 2. Condensations With Aromatic N-Aminoheterocycles And Elucidation Of Tautomeric Structures
Kurz Und Knapp:l-Glucose Undl-Glucuronsäure Ausd-Glucose
Hydrazones From Hydroxy Naphthaldehydes. Part 2. Condensations With Aromatic N-Aminoheterocycles And Elucidation Of Tautomeric Structures
(3r,4s,5r,6r,7s)-3,4,5,7-Tetrahydroxyconidine, An Azetidine Analogue Of 6,7-Diepicastanospermine And A Conformationally Constrained D- Deoxyaltronojirimycin, From L-Arabinose
Hydrazones From Hydroxy Naphthaldehydes. Part 2. Condensations With Aromatic N-Aminoheterocycles And Elucidation Of Tautomeric Structures
(3r,4s,5r,6r,7s)-3,4,5,7-Tetrahydroxyconidine, An Azetidine Analogue Of 6,7-Diepicastanospermine And A Conformationally Constrained D- Deoxyaltronojirimycin, From L-Arabinose
C-Branched Iminosugars: Α-Glucosidase Inhibition By Enantiomers Of Isodmdp, Isodgdp, And Isodab- L -Isodmdp Compared To Miglitol And Miglustat
(3r,4s,5r,6r,7s)-3,4,5,7-Tetrahydroxyconidine, An Azetidine Analogue Of 6,7-Diepicastanospermine And A Conformationally Constrained D- Deoxyaltronojirimycin, From L-Arabinose
C-Branched Iminosugars: Α-Glucosidase Inhibition By Enantiomers Of Isodmdp, Isodgdp, And Isodab- L -Isodmdp Compared To Miglitol And Miglustat
Azetidine Iminosugars From The Cyclization Of 3,5-Di- O -Triflates Of Α-Furanosides And Of 2,4-Di- O -Triflates Of Β-Pyranosides Derived From Glucose
C-Branched Iminosugars: Α-Glucosidase Inhibition By Enantiomers Of Isodmdp, Isodgdp, And Isodab- L -Isodmdp Compared To Miglitol And Miglustat
Azetidine Iminosugars From The Cyclization Of 3,5-Di- O -Triflates Of Α-Furanosides And Of 2,4-Di- O -Triflates Of Β-Pyranosides Derived From Glucose
N-(2-Carboxyethyl)-2,5-Dideoxy-2,5-Imino-D-Mannonic Acid [(3r,4r,5r)-1-(2-Carboxyethyl)-3,4-Dihydroxy-5-Hydroxymethyl-L-Proline]
Azetidine Iminosugars From The Cyclization Of 3,5-Di- O -Triflates Of Α-Furanosides And Of 2,4-Di- O -Triflates Of Β-Pyranosides Derived From Glucose
N-(2-Carboxyethyl)-2,5-Dideoxy-2,5-Imino-D-Mannonic Acid [(3r,4r,5r)-1-(2-Carboxyethyl)-3,4-Dihydroxy-5-Hydroxymethyl-L-Proline]
Glycosidase Inhibition By All 10 Stereoisomeric 2,5-Dideoxy-2,5- Iminohexitols Prepared From The Enantiomers Of Glucuronolactone
N-(2-Carboxyethyl)-2,5-Dideoxy-2,5-Imino-D-Mannonic Acid [(3r,4r,5r)-1-(2-Carboxyethyl)-3,4-Dihydroxy-5-Hydroxymethyl-L-Proline]
Glycosidase Inhibition By All 10 Stereoisomeric 2,5-Dideoxy-2,5- Iminohexitols Prepared From The Enantiomers Of Glucuronolactone
Synthesis From D-Altrose Of (5 R,6 R,7 R,8 S)-5,7-Dihydroxy-8- Hydroxymethylconidine And 2,4-Dideoxy-2,4-Imino-D-Glucitol, Azetidine Analogues Of Swainsonine And 1,4-Dideoxy-1,4-Imino-D-Mannitol
Glycosidase Inhibition By All 10 Stereoisomeric 2,5-Dideoxy-2,5- Iminohexitols Prepared From The Enantiomers Of Glucuronolactone
Synthesis From D-Altrose Of (5 R,6 R,7 R,8 S)-5,7-Dihydroxy-8- Hydroxymethylconidine And 2,4-Dideoxy-2,4-Imino-D-Glucitol, Azetidine Analogues Of Swainsonine And 1,4-Dideoxy-1,4-Imino-D-Mannitol
Tautomerism In Schiff Bases. The Cases Of 2-Hydroxy-1-Naphthaldehyde And 1-Hydroxy-2-Naphthaldehyde Investigated In Solution And The Solid State
Synthesis From D-Altrose Of (5 R,6 R,7 R,8 S)-5,7-Dihydroxy-8- Hydroxymethylconidine And 2,4-Dideoxy-2,4-Imino-D-Glucitol, Azetidine Analogues Of Swainsonine And 1,4-Dideoxy-1,4-Imino-D-Mannitol
Tautomerism In Schiff Bases. The Cases Of 2-Hydroxy-1-Naphthaldehyde And 1-Hydroxy-2-Naphthaldehyde Investigated In Solution And The Solid State
Schiff Bases From Tris And Ortho-Hydroxyarenecarbaldehydes: Structures And Tautomeric Equilibria In The Solid State And In Solution
Tautomerism In Schiff Bases. The Cases Of 2-Hydroxy-1-Naphthaldehyde And 1-Hydroxy-2-Naphthaldehyde Investigated In Solution And The Solid State
Schiff Bases From Tris And Ortho-Hydroxyarenecarbaldehydes: Structures And Tautomeric Equilibria In The Solid State And In Solution
A Quantitative Structure-Reactivity Relationship In N-Acetyl Oxazolidines: An Electrostatic Interaction Controls Rotamer Population
Schiff Bases From Tris And Ortho-Hydroxyarenecarbaldehydes: Structures And Tautomeric Equilibria In The Solid State And In Solution
A Quantitative Structure-Reactivity Relationship In N-Acetyl Oxazolidines: An Electrostatic Interaction Controls Rotamer Population
Hydrazones From Hydroxy Naphthaldehydes And N-Aminoheterocycles: Structure And Stereodynamics
A Quantitative Structure-Reactivity Relationship In N-Acetyl Oxazolidines: An Electrostatic Interaction Controls Rotamer Population
Hydrazones From Hydroxy Naphthaldehydes And N-Aminoheterocycles: Structure And Stereodynamics
Schiff Bases From Tris And Formylpyridines: Structure And Mechanistic Rationale Aided By Dft Calculations
Hydrazones From Hydroxy Naphthaldehydes And N-Aminoheterocycles: Structure And Stereodynamics
Schiff Bases From Tris And Formylpyridines: Structure And Mechanistic Rationale Aided By Dft Calculations
An Anomeric Effect Drives The Regiospecific Ring-Opening Of 1,3-Oxazolidines Under Acetylating Conditions
Schiff Bases From Tris And Formylpyridines: Structure And Mechanistic Rationale Aided By Dft Calculations
An Anomeric Effect Drives The Regiospecific Ring-Opening Of 1,3-Oxazolidines Under Acetylating Conditions
An Efficient And Highly Diastereoselective Synthesis Of C-Glycosylated 1,3-Oxazolidines From N-Methyl-D-Glucamine
An Anomeric Effect Drives The Regiospecific Ring-Opening Of 1,3-Oxazolidines Under Acetylating Conditions
An Efficient And Highly Diastereoselective Synthesis Of C-Glycosylated 1,3-Oxazolidines From N-Methyl-D-Glucamine
Catalytic Screening For 1,2-Diol Protection: A Saccharose-Derived Hydrothermal Carbon Showcases Enhanced Performance
WEB ACCESIBLE