PUBLICACIÓN
Disruption of ER-mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis
ACCEDER A LA PUBLICACIÓN:
Lau D.H.W. et al.
Cancer Research (Q1), Cell Biology (Q1), Cellular and Molecular Neuroscience (Q1), Immunology (Q1), Medicine (miscellaneous) (Q1)
JCR: 5.959
SJR: 2.31
CITAS
64
DOI
10.1038/s41419-017-0022-7
EID
2-s2.0-85043278650
EISSN
2041-4889
BIBTEX
@article{44276430cb4a4eec88c02ffe52663a14, title = 'Disruption of ER-mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis', abstract = 'Fronto-temporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two related and incurable neurodegenerative diseases. Features of these diseases include pathological protein inclusions in affected neurons with TAR DNA-binding protein 43 (TDP-43), dipeptide repeat proteins derived from the C9ORF72 gene, and fused in sarcoma (FUS) representing major constituent proteins in these inclusions. Mutations in C9ORF72 and the genes encoding TDP-43 and FUS cause familial forms of FTD/ALS which provides evidence to link the pathology and genetics of these diseases. A large number of seemingly disparate physiological functions are damaged in FTD/ALS. However, many of these damaged functions are regulated by signalling between the endoplasmic reticulum and mitochondria, and this has stimulated investigations into the role of endoplasmic reticulum-mitochondria signalling in FTD/ALS disease processes. Here, we review progress on this topic.', author = 'Lau, {Dawn H.W.} and Naomi Hartopp and Welsh, {Natalie J.} and Sarah Mueller and Glennon, {Elizabeth B.} and M{\'o}rotz, {G{\'a}bor M.} and Ambra Annibali and Patricia Gomez-Suaga and Radu Stoica and Sebastien Paillusson and Miller, {Christopher C.J.}', year = '2018', month = mar, day = '1', doi = '10.1038/s41419-017-0022-7', language = 'English', volume = '9', journal = 'Cell Death and Disease', issn = '2041-4889', publisher = 'Nature Publishing Group', number = '3', }
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