BIBTEX

@article{2612792b97d4489ba6650971000dcc63, title = 'The Interplay Between Autophagy and RNA Homeostasis: Implications for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia', abstract = 'Amyotrophic lateral sclerosis and frontotemporal dementia are neurodegenerative disorders that lie on a disease spectrum, sharing genetic causes and pathology, and both without effective therapeutics. Two pathways that have been shown to play major roles in disease pathogenesis are autophagy and RNA homeostasis. Intriguingly, there is an increasing body of evidence suggesting a critical interplay between these pathways. Autophagy is a multi-stage process for bulk and selective clearance of malfunctional cellular components, with many layers of regulation. Although the majority of autophagy research focuses on protein degradation, it can also mediate RNA catabolism. ALS/FTD-associated proteins are involved in many stages of autophagy and autophagy-mediated RNA degradation, particularly converging on the clearance of persistent pathological stress granules. In this review, we will summarise the progress in understanding the autophagy-RNA homeostasis interplay and how that knowledge contributes to our understanding of the pathobiology of ALS/FTD.', author = 'Houghton, {O H} and S Mizielinska and P Gomez-Suaga', note = 'Funding Information: This work was supported by the UK Dementia Research Institute which receives its funding from DRI Ltd., funded by the UK Medical Research Council, Alzheimer{\textquoteright}s Society and Alzheimer{\textquoteright}s Research UK (OH, SM), a PhD Studentship from Motor Neuron Disease Association (OH, SM, PG-S; Mizielinska/Oct19/896-792), and by a Fellowship to PG-S from the UK Motor Neurone Disease Association (Gomez-Suaga/Oct17/967/799) and from MICINN (Spain) by the Juan de la Cierva—Incorporaci{\'o}n programme (IJC 2019-039229-I). Publisher Copyright: Copyright {\textcopyright} 2022 Houghton, Mizielinska and Gomez-Suaga.', year = '2022', month = apr, day = '28', doi = '10.3389/fcell.2022.838402', language = 'English', volume = '10', pages = '838402', journal = 'Frontiers in Cell and Developmental Biology', issn = '2296-634X', publisher = 'Frontiers Media S.A.', }