PUBLICACIÓN
ER-mitochondria signaling in Parkinson's disease review-article
ACCEDER A LA PUBLICACIÓN:
Gomez-Suaga P., Bravo-San Pedro J.M., Gonzalez-Polo R.A., Fuentes J.M., Niso-Santano M.
Cancer Research (Q1), Cell Biology (Q1), Cellular and Molecular Neuroscience (Q1), Immunology (Q1), Medicine (miscellaneous) (Q1)
JCR: 5.959
SJR: 2.31
CITAS
127
DOI
10.1038/s41419-017-0079-3
EID
2-s2.0-85042859594
EISSN
2041-4889
BIBTEX
@article{733cd1fea4db4dcc9ce67887caf830ff, title = 'ER-mitochondria signaling in Parkinson's disease review-article', abstract = 'Mitochondria form close physical contacts with a specialized domain of the endoplasmic reticulum (ER), known as the mitochondria-associated membrane (MAM). This association constitutes a key signaling hub to regulate several fundamental cellular processes. Alterations in ER-mitochondria signaling have pleiotropic effects on a variety of intracellular events resulting in mitochondrial damage, Ca2+ dyshomeostasis, ER stress and defects in lipid metabolism and autophagy. Intriguingly, many of these cellular processes are perturbed in neurodegenerative diseases. Furthermore, increasing evidence highlights that ER-mitochondria signaling contributes to these diseases, including Parkinson's disease (PD). PD is the second most common neurodegenerative disorder, for which effective mechanism-based treatments remain elusive. Several PD-related proteins localize at mitochondria or MAM and have been shown to participate in ER-mitochondria signaling regulation. Likewise, PD-related mutations have been shown to damage this signaling. Could ER-mitochondria associations be the link between pathogenic mechanisms involved in PD, providing a common mechanism? Would this provide a pharmacological target for treating this devastating disease? In this review, we aim to summarize the current knowledge of ER-mitochondria signaling and the recent evidence concerning damage to this signaling in PD.', author = 'Patricia G{\'o}mez-Suaga and {Bravo-San Pedro}, {Jos{\'e} M.} and Gonz{\'a}lez-Polo, {Rosa A.} and Fuentes, {J. M.} and Mireia Niso-Santano', year = '2018', month = mar, day = '1', doi = '10.1038/s41419-017-0079-3', language = 'English', volume = '9', journal = 'Cell Death and Disease', issn = '2041-4889', publisher = 'Nature Publishing Group', number = '3', }
AUTORES DE LA UEX
OTRAS PUBLICACIONES DE INTERÉS
