PUBLICACIÓN
Mitochondria-Associated Membranes (MAMs): Overview and Its Role in Parkinson’s Disease
ACCEDER A LA PUBLICACIÓN:
Rodriguez-Arribas M., Yakhine-Diop S.M.S., Pedro J.M.B.-S., Gomez-Suaga P., Gomez-Sanchez R., Martinez-Chacon G., Fuentes J.M., Gonzalez-Polo R.A., Niso-Santano M.
Cellular and Molecular Neuroscience (Q2), Neurology (Q1), Neuroscience (miscellaneous) (Q1)
JCR: 5.076
SJR: 1.614
CITAS
69
DOI
10.1007/s12035-016-0140-8
EID
2-s2.0-84990848449
ISSN
0893-7648
EISSN
1559-1182
BIBTEX
@article{804ec83188c7422387a1a6011b0a791c, title = 'Mitochondria-Associated Membranes (MAMs): Overview and Its Role in Parkinson{\textquoteright}s Disease', abstract = 'Mitochondria-associated membranes (MAMs) are structures that regulate physiological functions between endoplasmic reticulum (ER) and mitochondria in order to maintain calcium signaling and mitochondrial biogenesis. Several proteins located in MAMs, including those encoded by PARK genes and some of neurodegeneration-related proteins (huntingtin, presenilin, etc.), ensure this regulation. In this regard, MAM alteration is associated with neurodegenerative diseases such as Parkinson{\textquoteright}s (PD), Alzheimer{\textquoteright}s (AD), and Huntington{\textquoteright}s diseases (HD) and contributes to the appearance of the pathogenesis features, i.e., autophagy dysregulation, mitochondrial dysfunction, oxidative stress, and lately, neuronal death. Moreover,, ER stress and/or damaged mitochondria can be the cause of these disruptions. Therefore, ER-mitochondria contact structure and function are crucial to multiple cellular processes. This review is focused on the molecular interaction between ER and mitochondria indispensable to MAM formation and on MAM alteration-induced etiology of neurodegenerative diseases.', keywords = 'Endoplasmic reticulum, Mitochondria, Neurodegenerative diseases, Parkinson{\textquoteright}s disease', author = 'M. Rodr{\'i}guez-Arribas and Yakhine-Diop, {S. M S} and Pedro, {J. M Bravo San} and P. G{\'o}mez-Suaga and R. G{\'o}mez-S{\'a}nchez and G. Mart{\'i}nez-Chac{\'o}n and Fuentes, {J. M.} and Gonz{\'a}lez-Polo, {R. A.} and M. Niso-Santano', year = '2016', month = oct, day = '6', doi = '10.1007/s12035-016-0140-8', language = 'English', pages = '1--17', journal = 'Molecular Neurobiology', issn = '0893-7648', publisher = 'Humana Press', }
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